Article
Genetics of inflammatory bowel disease: beyond NOD2.
The lancet. Gastroenterology & hepatology - 1 Mar 2017
Mirkov Maša Umićević, Verstockt Bram, Cleynen Isabelle
Abstract excerpt
The study of the genetic underpinnings of inflammatory bowel disease has made great progress since the identification of NOD2 as a major susceptibility gene. Novel genotyping and sequencing technologies have led to the discovery of 242 common susceptibility loci, 45 of which have been fine-mapped to statistically conclusive causal variants; 50 genes associated with very-early-onset inflammatory disease have been...
Topics
- Genetic Predisposition to Disease
- Genome-Wide Association Study
- Genotyping Techniques
- Humans
- Inflammatory Bowel Diseases
- Nod2 Signaling Adaptor Protein
- Sequence Analysis, DNA
- Translational Research, Biomedical