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Article

Prediction of Crohn's Disease Stricturing Phenotype Using a NOD2-derived Genomic Biomarker.

Inflammatory bowel diseases - 3 Apr 2023

Ashton James J, Cheng Guo, Stafford Imogen S, Kellermann Melina, Seaby Eleanor G, Cummings J R Fraser, Coelho Tracy A F, Batra Akshay, Afzal Nadeem A, Beattie R Mark, Ennis Sarah

Abstract excerpt

BACKGROUND: Crohn's disease (CD) is highly heterogenous and may be complicated by stricturing behavior. Personalized prediction of stricturing will inform management. We aimed to create a stricturing risk stratification model using genomic/clinical data. METHODS: Exome sequencing was performed on CD patients, and phenotype data retrieved. Biallelic variants in NOD2 were identified. NOD2 was converted into a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 36161322
DOI: 10.1093/ibd/izac205
PMCID: PMC10069659

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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