Article

Eta-secretase-like processing of the amyloid precursor protein (APP) by RHBDL4

2023-09-04

Abstract excerpt

The amyloid precursor protein (APP) has been extensively studied with regards to its contribution to the pathology of Alzheimer’s disease. APP is an ubiquitously expressed type I transmembrane protein synthesized in the endoplasmic reticulum (ER) and translocated to the plasma membrane where it undergoes proteolytic cleavages by several identified proteases. Conversely to other known proteases, we previously eluci...

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Literature Corpus work: e5a355d5-d920-5ea3-9ff7-f4b38ba40c65
DOI: 10.1101/2023.09.04.555897

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