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The Alzheimer’s disease associated bacterial protease RgpB from <i>P. gingivalis</i> activates the alternative β-secretase meprin β thereby increasing Aβ generation

2019-08-28

Abstract excerpt

Alzheimer’s disease (AD) is the most common type of dementia and characterized by tau hyperphosphorylation, oxidative stress, reactive microglia and amyloid-β (Aβ) deposits. A recent study revealed that Porphyromonas gingivalis infection is associated with amyloid β generation in Alzheimer’s disease. Increased Aβ levels, tau degradation and neuronal toxicity were observed as a consequence of ginigipain R (RgpB) a...

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Literature Corpus work
89597d0c-3020-5bf9-913c-05dc14fdcf3e
DOI
10.1101/748814
Open publication

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