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Article

Proteolytic processing of the amyloid-beta protein precursor of Alzheimer's disease.

Essays in biochemistry - 1 Jan 2002

Nunan Janelle, Small David H

Abstract excerpt

The proteolytic processing of the amyloid-beta protein precursor plays a key role in the development of Alzheimer's disease. Cleavage of the amyloid-beta protein precursor may occur via two pathways, both of which involve the action of proteases called secretases. One pathway, involving beta- and gamma-secretase, liberates amyloid-beta protein, a protein associated with the neurodegeneration seen in Alzheimer's...

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Source

Identifiers

PMID: 12463160
DOI: 10.1042/bse0380037

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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