Article

Systematic mutational mapping reveals optimal amyloid formation for RIPK function

2026-02-19

Abstract excerpt

Amyloid formation, typically associated with neurodegeneration, can also serve essential biological functions. RIPK1 and RIPK3 kinases assemble functional amyloids via their RHIM domains to drive necrosome formation and necroptosis. Here, we systematically map the sequence-function relationship of these domains using deep mutagenesis combined with massively parallel assays that directly report on amyloid nucleatio...

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Literature Corpus work: e5987f3c-ee98-5fa1-be22-1e2c062692e1
DOI: 10.64898/2026.02.19.706818

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