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Article

Crystal Structure of Ripk4 Reveals Dimerization-Dependent Kinase Activity.

Structure (London, England : 1993) - 1 May 2018

Huang Christine S, Oberbeck Nina, Hsiao Yi-Chun, Liu Peter, Johnson Adam R, Dixit Vishva M, Hymowitz Sarah G

Abstract excerpt

Receptor-interacting protein kinase 4 (RIPK4) is a highly conserved regulator of epidermal differentiation. Members of the RIPK family possess a common kinase domain as well as unique accessory domains that likely dictate subcellular localization and substrate preferences. Mutations in human RIPK4 manifest as Bartsocas-Papas syndrome (BPS), a genetic disorder characterized by severe craniofacial and limb...

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Share to Protein Multimerization
Share to Adenosine Triphosphate

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Protein Serine-Threonine Kinases

Share to Proto-Oncogene Proteins B-raf

Source

Identifiers

PMID: 29706531
DOI: 10.1016/j.str.2018.04.002

Genes

RIPK4
BRAF
RIPK2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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