Article

Temporal control of acute protein aggregate turnover by UBE3C and NRF1-dependent proteasomal pathways

2024-09-01

Abstract excerpt

A hallmark of neurodegenerative diseases is the progressive loss of proteostasis, leading to the accumulation of misfolded proteins or protein aggregates, with subsequent cytotoxicity. To combat this toxicity, cells have evolved degradation pathways (ubiquitin-proteasome system and autophagy) that detect and degrade misfolded proteins. However, studying the underlying cellular pathways and mechanisms has remained...

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Literature Corpus work: 76d969f1-a655-59f6-82a4-dbf739f007ad
DOI: 10.1101/2024.08.30.610524

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