Article

NEMO reshapes the protein aggregate interface and promotes aggrephagy by co-condensation with p62

2023-06-06

Abstract excerpt

<h4>ABSTRACT</h4> NEMO is a ubiquitin-binding protein which regulates canonical NF-κB pathway activation in innate immune signaling, cell death regulation and host-pathogen interactions. Here we identified an NF-κB-independent function of NEMO in proteostasis regulation by promoting autophagosomal clearance of protein aggregates. NEMO-deficient cells accumulate misfolded proteins upon proteotoxic stress and are v...

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Literature Corpus work: 309b47b2-4709-53fd-81db-434cb5fb5311
DOI: 10.1101/2023.06.05.543428

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