Article

A hydrophobic cluster controls long-range allostery in the TRMT2A RNA recognition motif

2025-11-06

Abstract excerpt

TRMT2A has emerged as a disease-modifying target in polyglutamine (PolyQ) models, yet the conformational preferences and allostery of its RNA recognition motif (RRM) remain poorly resolved. Here we combine extensive atomistic molecular dynamics with Markov state modeling (BHMSM), transition path theory, and structure-based pocket analysis to map the conformational landscape of the human TRMT2A RRM. We resolve six...

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Literature Corpus work: e58c2156-18f5-5ce7-899a-be37e1b20bc3
DOI: 10.1101/2025.11.05.686750

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