Article

Structural Pockets and Interacting RNA-Associated Ligands (SPIRAL): A DSSR-enabled Meta-Analysis of RNA-Small Molecule Recognition

2026-05-21

Abstract excerpt

<h4>ABSTRACT</h4> Small molecules that target structured RNA hold therapeutic promise across a wide range of diseases, yet the structural principles governing RNA–ligand recognition remain poorly defined. We present SPIRAL (Structural Pockets and Interacting RNA-Associated Ligands), a curated database of 1,098 RNA–small molecule structures from the Protein Data Bank covering 1,137 ligand-binding events across six...

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Literature Corpus work: d2024387-990b-5f5e-b33c-c751eb1a2e73
DOI: 10.64898/2026.05.19.726393

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