Critical Assessment of a Structure-Based Pipeline for Targeting the Long Non-Coding RNA MALAT1

Abstract excerpt

<h4>ABSTRACT</h4> Long non-coding RNAs (lncRNAs) are increasingly recognized as druggable targets due to their conserved secondary/tertiary structures and regulatory roles in disease. A prototypical example is the MALAT1 triple helix, whose stability supports transcript persistence and is implicated in oncogenesis. Here, we evaluate the ability of a structure-based drug discovery (SBDD) pipeline, integrating mole...

Topics

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• Base Pairing
• Base Sequence
• Computational Drug Discovery Methods
• Mutation
• Neoplasms
• Nucleic Acid Conformation
• Polymorphism, Single Nucleotide
• RNA, Long Noncoding

Identifiers and source

Literature Corpus work

37719afb-6e2b-54f9-9fa3-618be299f2c5

DOI

10.1101/2025.11.13.688270