Article

Markov State Models and NMR Uncover an Overlooked Allosteric Loop in p53

2020-10-19

Abstract excerpt

<h4>ABSTRACT</h4> The tumor suppressor p53 is the most frequently mutated gene in human cancer, and thus reactivation of mutated p53 is a promising avenue for cancer therapy. Analysis of wildtype p53 and the Y220C cancer mutant long-timescale molecular dynamics simulations with Markov state models and validation by NMR relaxation studies has uncovered the involvement of loop L6 in the slowest motions of the prote...

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Literature Corpus work: 981af551-b46f-5f0c-96bd-dd83b449cee1
DOI: 10.1101/2020.10.19.346023

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