Article
Chemical genomics: Functional analysis of orphan nuclear receptors in the regulation of bile acid metabolism
5 Oct 2001
Abstract excerpt
Chemical genomics is the name we have given to the analysis of gene function through use of small molecule chemical tools. Orphan nuclear receptors are ideally suited to this technique of functional analysis, since their activity as transcription factors is regulated by small hydrophobic ligands. GW4064 is a potent and selective nonsteroidal ligand for the nuclear bile acid receptor FXR (NR1H4). Using GW4064 as a...