Article

The development and characterization of bile acid-derived agonists of FXR towards NASH treatment

2020-01-01

Abstract excerpt

Over the last few decades, bile acids (BAs) have emerged as important hormone-like signalling molecules. Bile acids have been shown to exert their effects through the binding and activation of the Farnesoid X Receptor (FXR), which regulates various pleiotropic target genes underlying bile acid homeostasis, inflammation and lipid, glucose and cholesterol metabolism. FXR plays a pivotal role in the aetiology of vari...

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Literature Corpus work: 746e9e68-4669-5b3d-8058-9806a49e81a4
DOI: 10.48683/1926.00089318

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