Article

Expansion of mutation-driven haematopoietic clones is associated with insulin resistance and low HDL-cholesterol in individuals with obesity

2021-05-13

Abstract excerpt

<h4>Aims</h4> Haematopoietic clones caused by somatic mutations with ≥2% variant allele frequency (VAF), known as clonal haematopoiesis of indeterminate potential (CHIP), increase with age and have been linked to risk of haematological malignancies and cardiovascular disease. Recent observations suggest that smaller clones are also associated with adverse clinical outcomes. Our aims were to determine the prevalen...

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Literature Corpus work: e5734b6c-046b-5dd9-89eb-4add7fc19546
DOI: 10.1101/2021.05.12.443095

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