Article
Evolution of age-related mutation-driven clonal haematopoiesis over 20 years is associated with metabolic dysfunction in obesity.
EBioMedicine - 1 Jun 2023
Andersson-Assarsson Johanna C, van Deuren Rosanne C, Kristensson Felipe M, Steehouwer Marloes, Sjöholm Kajsa, Svensson Per-Arne, Pieterse Marc, Gilissen Christian, Taube Magdalena, Jacobson Peter, Perkins Rosie, Brunner Han G, Netea Mihai G, Peltonen Markku, Carlsson Björn, Hoischen Alexander, Carlsson Lena M S
Abstract excerpt
BACKGROUND: Haematopoietic clones caused by somatic mutations with ≥2% variant allele frequency (VAF) increase with age and are linked to risk of haematological malignancies and cardiovascular disease. Recent observations suggest that smaller clones (VAF<2%) are also associated with adverse outcomes. Our aims were to determine the prevalence of clonal haematopoiesis driven by clones of variable sizes in...
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