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Article

Parkinson's disease-associated mutant LRRK2 phosphorylates Rab7L1 and modifies trans-Golgi morphology.

Biochemical and biophysical research communications - 8 Jan 2018

Fujimoto Tetta, Kuwahara Tomoki, Eguchi Tomoya, Sakurai Maria, Komori Tadayuki, Iwatsubo Takeshi

Abstract excerpt

Mutations in leucine-rich repeat kinase 2 (LRRK2) are the major genetic cause of autosomal-dominantly inherited Parkinson's disease. LRRK2 is implicated in the regulation of intracellular trafficking, neurite outgrowth and PD risk in connection with Rab7L1, a putative interactor of LRRK2. Recently, a subset of Rab GTPases have been reported as substrates of LRRK2. Here we examine the kinase activity of LRRK2 on...

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PMID: 29223392
DOI: 10.1016/j.bbrc.2017.12.024

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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