Article

Preclinical evaluation of the novel [ <sup>18</sup> F]CHDI-650 PET ligand for non-invasive quantification of mutant huntingtin aggregates in Huntington’s disease

2024-05-16

Abstract excerpt

<h4>Purpose</h4> Positron emission tomography (PET) imaging of mutant huntingtin (mHTT) aggregates is a potential tool to monitor disease progression as well as the efficacy of candidate therapeutic interventions for Huntington’s disease (HD). To date, the focus has been mainly on the investigation of 11 C radioligands; however, favourable 18 F radiotracers will facilitate future clinical translation. This work...

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Literature Corpus work: e5694113-c897-5a95-b54b-055601fc3040
DOI: 10.1101/2024.05.16.594492

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