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Article

In Vivo PET Imaging of [18F]CHDI-385, a Radioligand for Mutant Huntingtin Aggregates in a Mouse Model of Huntington Disease.

Journal of nuclear medicine : official publication, Society of Nuclear Medicine - 2 Feb 2026

Zajicek Franziska, Elvas Filipe, Miranda Alan, Akkermans Jordy, Verhaeghe Jeroen, Dominguez Celia, Doot Robert, Khetarpal Vinod, Bard Jonathan, Liu Longbin, Staelens Steven, Bertoglio Daniele

Abstract excerpt

Aggregation of mutant huntingtin (mHTT) is a neurologic hallmark of Huntington disease (HD), a neurodegenerative disorder caused by the expansion of a cytosine-adenine-guanine repeat tract in the huntingtin gene (HTT). With a considerable number of candidate therapeutic interventions aimed at lowering mHTT expression under investigation, noninvasive monitoring of changes in mHTT aggregate levels in the brain...

Topics

Animals
Huntington Disease
Positron-Emission Tomography
Mice
Disease Models, Animal
Huntingtin Protein
Mutation
Brain
Fluorine Radioisotopes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Protein Aggregates

Ligands

Male

Radiopharmaceuticals

Source

Open in PubMed Open full text

Identifiers

PMID: 41233147
DOI: 10.2967/jnumed.125.270660
PMCID: PMC12866408

Genes

HTT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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Click a neighbor to travelStep 1 · 12 closest

In Vivo PET Imaging of [18F]CHDI-385, a Radioligand for Mutant Huntingtin Aggregates in a Mouse Model of Huntington Disease.PMID 41233147Read ↗

Preclinical evaluation of [ <sup>11</sup> C]CHDI-009R for quantification of mutant huntingtin aggregatesSemantic proximity Read ↗

Preclinical evaluation of [11C]CHDI-009R for quantification of mutant huntingtin aggregatesSemantic proximity Read ↗

Preclinical evaluation of the novel [18F]CHDI-650 PET ligand for non-invasive quantification of mutant huntingtin aggregates in Huntington's disease.Semantic proximity Read ↗

PET imaging with [¹¹C]CHDI-00485180-R, designed as radioligand for aggregated mutant huntingtin, in people with Huntington's disease.Semantic proximity Read ↗

In Vivo Cerebral Imaging of Mutant Huntingtin Aggregates Using11C-CHDI-180R PET in a Nonhuman Primate Model of Huntington DiseaseSemantic proximity Read ↗

Preclinical evaluation of the novel [ <sup>18</sup> F]CHDI-650 PET ligand for non-invasive quantification of mutant huntingtin aggregates in Huntington’s diseaseSemantic proximity Read ↗

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Development of a ligand for in vivo imaging of mutant huntingtin in Huntington’s diseaseSemantic proximity Read ↗

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Pharmacological characterization of mutant huntingtin aggregate-directed PET imaging tracer candidatesSemantic proximity Read ↗

Rodent biodistribution and dosimetry of the PET radioligands [18F]CHDI-385 and [18F]CHDI-386 targeting mutant huntingtin aggregates.Semantic proximity Read ↗

Biodistribution and dosimetry of the PET radioligand [18F]CHDI-650 in mice for detection of mutant huntingtin aggregatesSemantic proximity Read ↗

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