Article
Rodent biodistribution and dosimetry of the PET radioligands [18F]CHDI-385 and [18F]CHDI-386 targeting mutant huntingtin aggregates.
Nuclear medicine and biology - 1 Jan 2026
Akkermans Jordy, Miranda Alan, Verhaeghe Jeroen, Elvas Filipe, Zajicek Franziska, Bard Jonathan, Liu Longbin, Khetarpal Vinod, Doot Robert, Staelens Steven, Bertoglio Daniele
Abstract excerpt
BACKGROUND: Huntington's disease is a neurodegenerative condition resulting from an expanded CAG repeat in the huntingtin gene that produces a mutant form of the huntingtin protein (mHTT). In this study we estimated the radiation safety of two structurally related mHTT radioligands, [18F]CHDI-385 and [18F]CHDI-386, by evaluating the in vivo and ex vivo dosimetry of both radioligands using CD-1 Swiss mice....
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