Article
PET imaging with [¹¹C]CHDI-00485180-R, designed as radioligand for aggregated mutant huntingtin, in people with Huntington's disease.
European journal of nuclear medicine and molecular imaging - 1 Nov 2025
Delva Aline, Koole Michel, Serdons Kim, Bormans Guy, Skinbjerg Mette, Khetarpal Vinod, Liu Longbin, Bard Jonathan, Doot Robert, Warner John H, Sathe Swati, Sampaio Cristina, Wood Andrew, Van Laere Koen, Vandenberghe Wim
Abstract excerpt
PURPOSE: [11C]CHDI-00485180-R ([11C]CHDI-180R) is a novel PET radioligand developed to image aggregated mutant huntingtin (mHTT). Data from mouse models of Huntington's disease (HD) and biodistribution studies in healthy volunteers suggested that [11C]CHDI-180R is a promising candidate for in vivo determination of cerebral aggregated mHTT levels using PET. In the iMagemHTT study reported here, we investigated...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.