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Preclinical evaluation of the novel [18F]CHDI-650 PET ligand for non-invasive quantification of mutant huntingtin aggregates in Huntington's disease.

European journal of nuclear medicine and molecular imaging - 1 Dec 2024

Zajicek Franziska, Verhaeghe Jeroen, De Lombaerde Stef, Van Eetveldt Annemie, Miranda Alan, Munoz-Sanjuan Ignacio, Dominguez Celia, Khetarpal Vinod, Bard Jonathan, Liu Longbin, Staelens Steven, Bertoglio Daniele

Abstract excerpt

PURPOSE: Positron emission tomography (PET) imaging of mutant huntingtin (mHTT) aggregates is a potential tool to monitor disease progression as well as the efficacy of candidate therapeutic interventions for Huntington's disease (HD). To date, the focus has been mainly on the investigation of 11C radioligands; however, favourable 18F radiotracers will facilitate future clinical translation. This work aimed at...

Topics

Huntington Disease
Animals
Positron-Emission Tomography
Huntingtin Protein
Mice
Fluorine Radioisotopes
Protein Aggregates
Ligands
Brain

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Male

Radiopharmaceuticals

Disease Models, Animal

Source

Open in PubMed Open full text

Identifiers

PMID: 39190197
DOI: 10.1007/s00259-024-06880-x
PMCID: PMC11599348

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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Preclinical evaluation of the novel [18F]CHDI-650 PET ligand for non-invasive quantification of mutant huntingtin aggregates in Huntington's disease.PMID 39190197Read ↗

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