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Pan‐cancer RNA‐seq data stratifies tumours by some hallmarks of cancer

15 Nov 2019

Abstract excerpt

Numerous genetic and epigenetic alterations cause functional changes in cell biology underlying cancer. These hallmark functional changes constitute potentially tissue-independent anticancer therapeutic targets. We hypothesized that RNA-Seq identifies gene expression changes that underly those hallmarks, and thereby defines relevant therapeutic targets. To test this hypothesis, we analysed the publicly available...

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PMID: 31730267
DOI: 10.1111/jcmm.14746

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