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Article

Macrophage-Derived IL1β and TNFα Regulate Arginine Metabolism in Neuroblastoma

13 Dec 2018

Abstract excerpt

Abstract Neuroblastoma is the most common childhood solid tumor, yet the prognosis for high-risk disease remains poor. We demonstrate here that arginase 2 (ARG2) drives neuroblastoma cell proliferation via regulation of arginine metabolism. Targeting arginine metabolism, either by blocking cationic amino acid transporter 1 (CAT-1)–dependent arginine uptake in vitro or therapeutic depletion of arginine by...

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PMID: 30545920
DOI: 10.1158/0008-5472.can-18-2139

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