Article

A spatial cell atlas of neuroblastoma reveals developmental, epigenetic and spatial axis of tumor heterogeneity

2024-01-07

Abstract excerpt

<h4>SUMMARY</h4> Neuroblastoma is a pediatric cancer arising from the developing sympathoadrenal lineage with complex inter- and intra-tumoral heterogeneity. To chart this complexity, we generated a comprehensive cell atlas of 55 neuroblastoma patient tumors, collected from two pediatric cancer institutions, spanning a range of clinical, genetic, and histologic features. Our atlas combines single-cell/nucleus RNA...

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Literature Corpus work: 99b2fdca-5aef-58b2-b4bb-88564d1a65dd
DOI: 10.1101/2024.01.07.574538

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