Article

Cytokine signaling converging on <i>IL11</i> in ILD fibroblasts provokes aberrant epithelial differentiation signatures

2022-12-20

Abstract excerpt

Interstitial lung disease (ILD) is a heterogenous group of lung disorders where destruction and incomplete regeneration of the lung parenchyma often results in persistent architectural distortion of the pulmonary scaffold. Continuous mesenchyme-centered, disease-relevant signaling likely initiates and perpetuates the fibrotic remodeling process, specifically targeting the epithelial cell compartment, thereby destr...

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Literature Corpus work: e549765e-a1bc-5bdc-b136-c879392cc219
DOI: 10.1101/2022.12.20.521114

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