Article
NetSig: network-based discovery from cancer genomes.
Nature methods - 1 Jan 2018
Horn Heiko, Lawrence Michael S, Chouinard Candace R, Shrestha Yashaswi, Hu Jessica Xin, Worstell Elizabeth, Shea Emily, Ilic Nina, Kim Eejung, Kamburov Atanas, Kashani Alireza, Hahn William C, Campbell Joshua D, Boehm Jesse S, Getz Gad, Lage Kasper
Abstract excerpt
Methods that integrate molecular network information and tumor genome data could complement gene-based statistical tests to identify likely new cancer genes; but such approaches are challenging to validate at scale, and their predictive value remains unclear. We developed a robust statistic (NetSig) that integrates protein interaction networks with data from 4,742 tumor exomes. NetSig can accurately classify...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.