Article

Modeling Thick Filament Activation Suggests a Molecular Basis for Force Depression

2023-09-29

Abstract excerpt

<h4>ABSTRACT</h4> Multiscale models aiming to connect muscle’s molecular and cellular function have been difficult to develop, in part, due to a lack of self-consistent multiscale data. To address this gap, we measured the force response from single skinned rabbit psoas muscle fibers to ramp shortenings and step stretches performed on the plateau region of the force-length relationship. We isolated myosin from th...

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Literature Corpus work: e52ce285-459a-5751-8c5f-6ad2c6663629
DOI: 10.1101/2023.09.27.559764

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