Article

Piperine activates the thick filament of resting rat skeletal muscle, enhancing dynamic contractility in a fibre-type-dependent manner

2025-11-27

Abstract excerpt

The myosin-containing thick filament has recently been shown to alter its resting activation level in response to multiple diseases and therapeutics. Changes in thick filament resting activation level are caused by myosin heads transitioning between OFF and ON conformational states. Functionally, this modulation of thick filament activation level is a key regulatory step in muscle contraction and a promising thera...

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Literature Corpus work: c4ddd82b-92ac-5349-9e07-488c390eda46
DOI: 10.1101/2025.11.24.689918

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