Article
Effects of actin-myosin kinetics on the calcium sensitivity of regulated thin filaments.
The Journal of biological chemistry - 10 Dec 2010
Sich Nicholas M, O'Donnell Timothy J, Coulter Sarah A, John Olivia A, Carter Michael S, Cremo Christine R, Baker Josh E
Abstract excerpt
Activation of thin filaments in striated muscle occurs when tropomyosin exposes myosin binding sites on actin either through calcium-troponin (Ca-Tn) binding or by actin-myosin (A-M) strong binding. However, the extent to which these binding events contributes to thin filament activation remains unclear. Here we propose a simple analytical model in which strong A-M binding and Ca-Tn binding independently...
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