Article

Genomic alterations drive brain metastases formation in colorectal cancer: The role of IRS2

2022-06-12

Abstract excerpt

<h4>ABSTRACT</h4> Colorectal cancer (CRC) is currently the fourth leading etiology of brain metastasis (BM). Yet, mechanisms supporting the formation of CRC BM are mostly unknown. In order to identify drivers that lead to tropism and adaptation of CRC cells to the brain environment, we analyzed an extensive genomic database, consisting of over 36,000 human CRC primary and metastasis samples. Several genomic alter...

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Literature Corpus work: dfd73476-aa69-5e29-8b37-39511952839b
DOI: 10.1101/2022.06.10.495658

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