Article
Ex vivo modeling of morphological, molecular and pharmacological tumor heterogeneity of metastatic colorectal cancer
2025-05-09
Abstract excerpt
<title>Abstract</title> <p>This study reports the establishment and pharmacogenomics analyses of tumor heterogeneity in a living biobank of tumor organoids of 213 liver metastases from 102 patients with metastatic colorectal cancer. Successful organoid culturing reflected poorer chemosensitivity and patient survival. Molecular fidelity was demonstrated in tumor-organoid sample pairs, and multi-modal phenotypes we...
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Identifiers and source
- Literature Corpus work
- 334f7fb8-a6d7-599e-9903-518a9ad72bef
- DOI
- 10.21203/rs.3.rs-6507406/v1