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Article

The heterogeneous clinical and pathological landscapes of metastatic Braf-mutated colorectal cancer

29 Jan 2020

Abstract excerpt

Abstract Colorectal cancer (CRC) is a complex and molecularly heterogeneous disease representing one of the most frequent causes of cancer-related death worldwide. About 8–15% of CRCs harbor a mutation inBRAFgene, a proto-oncogene involved in cell proliferation, differentiation and survival through the MAPK signaling cascade. The acquisition ofBRAFmutation is an early event in the “serrated” CRC carcinogenetic...

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PMID: 32015690
DOI: 10.1186/s12935-020-1117-2

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