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Article

Multiple allelic configurations govern long-range Shh enhancer-promoter communication in the embryonic forebrain.

Molecular cell - 19 Dec 2024

Harke Jailynn, Lee Jeewon R, Nguyen Son C, Arab Arian, Rakowiecki Staci M, Hugelier Siewert, Paliou Christina, Rauseo Antonella, Yunker Rebecca, Xu Kellen, Yao Yao, Lakadamyali Melike, Andrey Guillaume, Epstein Douglas J, Joyce Eric F

Abstract excerpt

Developmental gene regulation requires input from enhancers spread over large genomic distances. Our understanding of long-range enhancer-promoter (E-P) communication, characterized as loops, remains incomplete without addressing the role of intervening chromatin. Here, we examine the topology of the entire Sonic hedgehog (Shh) regulatory domain in individual alleles from the mouse embryonic forebrain. Through...

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PMID: 39579767
DOI: 10.1016/j.molcel.2024.10.042
PMCID: PMC11663103

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CTCF

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