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Toll-like receptor-2 (TLR-2) rs111200466 variant offers protection against SARS-CoV-2 infections and mortality: a worldwide epidemiological correlation analysis.

Nucleosides, nucleotides & nucleic acids - 1 Jan 2023

Nayak Nisha, Pati Abhijit, Nahak Suraj Kumar, Sarangi Surjyapratap, Pradhan Bidyutprabha, Padhi Sunali, Panda Aditya K

Abstract excerpt

Recently Toll-like receptor-2 has been shown to sense the envelope protein of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) and initiate the production of inflammatory molecules. The expression and function of the TLR2 has been associated with several functional polymorphisms such as a 23 bp ins/del (rs111200466), Arg677Trp (rs121917864), and Arg753Gln (rs5743708). In the present study, we...

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PMID: 36472302
DOI: 10.1080/15257770.2022.2151015

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