Article

Isolation and characterization of human monoclonal antibodies to pneumococcal capsular polysaccharide 3

2021-08-03

Abstract excerpt

<h4>ABSTRACT</h4> The current pneumococcal capsular polysaccharide (PPS) conjugate vaccine (PCV13) is less effective against Streptococcus pneumoniae serotype 3 (ST3), which remains a major cause of pneumococcal disease and mortality. Therefore, dissecting structure-function relationships of human PPS3 antibodies may reveal characteristics of protective antibodies. Using flow cytometry, we isolated PPS3-binding...

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Literature Corpus work: e4e58872-6705-5202-8bf3-c8b8db52d241
DOI: 10.1101/2021.08.02.454853

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