Article

The increased hinge flexibility of an IgG1-IgG3 hybrid monoclonal enhances Fc-mediated protection against group A streptococci

2023-10-18

Abstract excerpt

Antibodies are central to the immune response against microbes. We have previously generated a protective IgG1 monoclonal antibody targeting the M protein, a critical virulence factor of Streptococcus pyogenes. Here, we generated this antibody in all human IgG subclasses and evaluated their function. Despite significantly reduced binding, the IgG3 subclass antibody demonstrated remarkably enhanced opsonic functio...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 3d31db7e-0a1d-5db7-a75c-32540d2070a1
DOI: 10.1101/2023.10.14.562368

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

The increased hinge flexibility of an IgG1-IgG3 hybrid monoclonal enhances Fc-mediated protection against group A streptococciDOI 10.1101/2023.10.14.562368Read

The hinge-engineered IgG1-IgG3 hybrid subclass IgGh47 potently enhances Fc-mediated function of anti-streptococcal and SARS-CoV-2 antibodiesSemantic proximity Read

A Primer for Junior Trainees: The Structure, Binding, and Therapeutic Applications of Immunoglobulin GSemantic proximity Read

Human IgG1, IgG3, and IgG3 Hinge-Truncated Mutants Show Different Protection Capabilities against Meningococci Depending on the Target Antigen and Epitope SpecificitySemantic proximity Read

Complement is activated by elevated IgG3 hexameric platforms and deposits C4b onto distinct antibody domainsSemantic proximity Read

A human monoclonal antibody bivalently binding two different epitopes in streptococcal M protein protects against infectionSemantic proximity Read

Mapping affinity and allostery in human IgG antibody Fc region-Fc γ receptor interactionsSemantic proximity Read

A human monoclonal antibody bivalently binding two different epitopes in streptococcal M protein mediates immune functionSemantic proximity Read

The Influence of Variable-Heavy (V H ) Chain Families on IgG 2 , 3 , 4 on FcγRs and Antibody Superantigens Protein G and L Binding using Biolayer InterferometrySemantic proximity Read

Potent TRIM21 and complement-dependent intracellular antiviral immunity requires the IgG3 hingeSemantic proximity Read

Mutation of Y407 in the CH3 domain dramatically alters glycosylation and structure of human IgG.Semantic proximity Read

Design and Evaluation of Meningococcal Vaccines through Structure-Based Modification of Host and Pathogen MoleculesSemantic proximity Read

Profiling the Biophysical Developability Properties of Common IgG1 Fc Effector Silencing VariantsSemantic proximity Read