Article
Immunogenetic analysis of the immune response to pneumococcal polysaccharide.
European journal of immunology - 1 Apr 2000
Baxendale H E, Davis Z, White H N, Spellerberg M B, Stevenson F K, Goldblatt D
Abstract excerpt
Pneumococcal serotype-specific anti-capsular polysaccharide antibodies protect against invasive pneumococcal disease. Within an individual the diversity of these antibodies is limited. To evaluate the repertoire of antibodies to pneumococcus and determine whether oligoclonality is seen both between serotypes and between individuals, we sampled the B cell repertoire induced by polysaccharide and conjugate vaccine...
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