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Ca2+ homeostasis maintained by TMCO1 underlies corpus callosum development via ERK signaling

4 Aug 2022

Abstract excerpt

Abstract Transmembrane of coiled-coil domains 1 (TMCO1) plays an important role in maintaining homeostasis of calcium (Ca2+) stores in the endoplasmic reticulum (ER). TMCO1-defect syndrome shares multiple features with human cerebro-facio-thoracic (CFT) dysplasia, including abnormal corpus callosum (CC). Here, we report that TMCO1 is required for the normal development of CC through sustaining...

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PMID: 35927240
DOI: 10.1038/s41419-022-05131-x

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