Article

Evidence for compensatory evolution within pleiotropic regulatory elements

2024-01-11

Abstract excerpt

Pleiotropy, measured as expression breadth across tissues, is one of the best predictors for protein sequence and expression conservation. In this study, we investigated its effect on the evolution of cis-regulatory elements (CREs). To this end, we carefully reanalyzed the Epigenomics Roadmap data for nine fetal tissues, assigning a measure of pleiotropic degree to nearly half a million CREs. To assess the functio...

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Literature Corpus work: e4d6ef42-9459-5317-ab7c-cd466d151224
DOI: 10.1101/2024.01.10.575014

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