Article
Functional Determinants and Evolutionary Consequences of Pleiotropy in Complex and Mendelian Traits.
Molecular biology and evolution - 1 Oct 2025
Barbitoff Yury A, Bogaichuk Polina M, Pavlova Nadezhda S, Malysheva Polina V, Predeus Alexander V
Abstract excerpt
Pleiotropy, a phenomenon of multiple phenotypic effects of the same genetic alteration, is one of the most important features of genotype-to-phenotype networks. Over the last century, biologists have actively debated the prevalence, mechanisms, and consequences of pleiotropy. In this work, we employed data on genotype-to-phenotype associations from the Human Phenotype Ontology and Mouse Genome Database, as well...
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