Article

Systematic Elucidation and Pharmacological Targeting of Tumor-Infiltrating Regulatory T Cell Master Regulators

2022-02-23

Abstract excerpt

Due to their immunosuppressive role, tumor-infiltrating regulatory T cells (TI-Tregs) represent attractive therapeutic targets. Analysis of TI vs. peripheral Tregs (P-Tregs) from 36 patients, across four malignancies, identified 17 candidate Master Regulators (MRs), predicted to mechanistically regulate TI-Tregs transcriptional state. In vivo , pooled CRISPR-KO screening, using a hematopoietic stem cell transplan...

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Literature Corpus work: 90eac1cd-001a-5243-b184-2f9c89026e21
DOI: 10.1101/2022.02.22.481404

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