Article

Endogenous CGRP activates NRF2 signaling via non-electrophilic mechanisms

2025-04-27

Abstract excerpt

The transcription factor nuclear factor erythroid 2-related factor 2 (NRF2) is crucial for regulating cellular responses to oxidative stress, making it a significant target for therapeutic interventions. While exogenous NRF2 activators offer significant therapeutic potential, their predominantly electrophilic nature poses considerable challenges for clinical use; the heightened electrophilic reactivity required to...

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Literature Corpus work: e4adfdf1-63b5-5ffa-931d-ccd24e7655c5
DOI: 10.1101/2025.04.25.650677

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