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Article

Induction of the Nrf2-driven antioxidant response confers neuroprotection during mitochondrial stress in vivo.

The Journal of biological chemistry - 17 Jun 2005

Shih Andy Y, Imbeault Sophie, Barakauskas Vilte, Erb Heidi, Jiang Lei, Li Ping, Murphy Timothy H

Abstract excerpt

NF-E2 related factor (Nrf2) controls a pleiotropic cellular defense, where multiple antioxidant/detoxification pathways are up-regulated in unison. Although small molecule inducers of Nrf2 activity have been reported to protect neurons in vitro, whether similar pathways can be accessed in vivo is not known. We have investigated whether in vivo toxicity of the mitochondrial complex II inhibitor 3-nitropropionic...

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PMID: 15840590
DOI: 10.1074/jbc.M414635200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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