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Article

Induction of the Nrf2-driven antioxidant response confers neuroprotection during mitochondrial stress in vivo.

The Journal of biological chemistry - 17 Jun 2005

Shih Andy Y, Imbeault Sophie, Barakauskas Vilte, Erb Heidi, Jiang Lei, Li Ping, Murphy Timothy H

Abstract excerpt

NF-E2 related factor (Nrf2) controls a pleiotropic cellular defense, where multiple antioxidant/detoxification pathways are up-regulated in unison. Although small molecule inducers of Nrf2 activity have been reported to protect neurons in vitro, whether similar pathways can be accessed in vivo is...

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PMID: 15840590
DOI: 10.1074/jbc.M414635200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-15840590-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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