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Ellagic acid protects from rotenone-induced dopaminergic neuronal damage via activation of Nrf2 signaling in astroglia

2020-01-08

Abstract excerpt

<h4>Background: </h4> Parkinson’s disease (PD) is the second most prevalent central nervous system (CNS) degenerative disease. Oxidative stress is one of key contributors to the degeneration of dopamine (DA) neurons in the pathogenesis of PD. Nuclear factor erythroid-2-related factor 2 (Nrf2) is considered to be a ‘master regulator’ of many genes involved in anti-oxidant stress to attenuate cell death. Therefore,...

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Literature Corpus work
56718945-4234-5f78-816e-a59dd37e2eb3
DOI
10.21203/rs.2.20298/v1
Open publication

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