Article

Preoptic area controls sleep-related seizure onset in a genetic epilepsy mouse model

2023-11-24

Abstract excerpt

In genetic and refractory epileptic patients, seizure activity exhibits sleep-related modulation/regulation and sleep and seizure are intermingled. In this study, by using one het Gabrg2 Q390X KI mice as a genetic epilepsy model and optogenetic method in vivo , we found that subcortical POA neurons were active within epileptic network from the het Gabrg2 Q390X KI mice and the POA activity preceded epileptic (...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: e4a8e0af-221f-57d1-b374-95bf3bc6ab97
DOI: 10.1101/2023.11.24.568593

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Preoptic area controls sleep-related seizure onset in a genetic epilepsy mouse modelDOI 10.1101/2023.11.24.568593Read

Sleep slow-wave oscillations trigger seizures in a genetic epilepsy model of Dravet syndromeSemantic proximity Read

Impaired state-dependent potentiation of GABAergic synaptic currents triggers seizures in an idiopathic generalized epilepsy modelSemantic proximity Read

Mice harboring the T316N variant in the GABAAR γ2 subunit exhibit sleep-related hypermotor epilepsy phenotypes and hypersynchronization in the thalamocortical pathway.Semantic proximity Read

Abnormal electrophysiological phenotypes and sleep deficits in a mouse model of Angelman SyndromeSemantic proximity Read

Absence seizures and sleep-wake abnormalities in a rat model of <i>GRIN2B</i> neurodevelopmental disorderSemantic proximity Read

Altered sleep regulation in a mouse model of SCN1A-derived genetic epilepsy with febrile seizures plus (GEFS+).Semantic proximity Read

Abnormal electrophysiological phenotypes and sleep deficits in a mouse model of Angelman Syndrome.Semantic proximity Read

GABAergic signaling promotes early-life seizures in epileptic SYNGAP1 <sup>+/-</sup> miceSemantic proximity Read

Glutamatergic neurons in the preoptic hypothalamus promote wakefulness, destabilize NREM sleep, suppress REM sleep, and regulate cortical dynamicsSemantic proximity Read

A novel mouse model of focal limbic seizures that reproduces behavioral impairment associated with cortical slow wave activitySemantic proximity Read

Circadian Rhythms and Epilepsy: A Suitable Case for Absence EpilepsySemantic proximity Read

Electrobehavioral phenotype and seizure pharmacosensitivity in a novel mouse model of patient-derived <i>SLC6A1</i> S295L mutation-associated neurodevelopmental epilepsySemantic proximity Read