Article

A novel mouse model of focal limbic seizures that reproduces behavioral impairment associated with cortical slow wave activity

2021-05-06

Abstract excerpt

Patients with focal temporal lobe seizures often experience loss of consciousness. In humans, this loss of consciousness has been shown to be positively correlated with EEG neocortical slow waves, similar to those seen in non-REM sleep. Previous work in rat models of temporal lobe seizures suggests that decreased activity of subcortical arousal systems cause depressed cortical function during seizures. However, th...

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Identifiers and source

Literature Corpus work: d91191c0-834c-5408-b2a2-eead4912c984
DOI: 10.1101/2021.05.05.442811

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