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A Carboxylate Switch Point Controls Long-Range Energy Transduction in Respiratory Complex I

2026-01-30

Abstract excerpt

Complex I is a highly intricate membrane-bound protein that powers the cellular energy metabolism by a long-range (>300 Å) proton-coupled electron transfer (PCET) reaction. Here, we investigate the unknown coupling mechanism of Complex I by probing the charge transfer reaction along its functionally central carboxylate pathway (E-channel). By combining biophysical and site-directed mutagenesis experiments with hig...

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Literature Corpus work
e49e3696-9fa4-597b-ae7b-dbbf443dc8ba
DOI
10.64898/2026.01.27.702182
Open publication

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