Article
Mutation at the entrance of the quinone cavity severely disrupts quinone binding in respiratory complex I.
Scientific reports - 21 Nov 2023
Yi Jason Tae, Wang Panyue, Stuchebrukhov Alexei A
Abstract excerpt
In all resolved structures of complex I, there exists a tunnel-like Q-chamber for ubiquinone binding and reduction. The entrance to the Q-chamber in ND1 subunit forms a narrow bottleneck, which is rather tight and requires thermal conformational changes for ubiquinone to get in and out of the binding chamber. The substitution of alanine with threonine at the bottleneck (AlaThr MUT), associated with 3460/ND1 mtDNA...
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